含窒素環化合物の合成 (第105報)

ベンゾチアゾール誘導体について その9

抄録

In order to examine the analgesic activity, 2-(2-dimethylaminoacylamido) benzothiazoles (III) were synthesized by the application of 2-bromoacyl bromide to 6-alkoxyor 4 (5, or 6)-chloro-2-aminobenzothizole (I) to the 2-(2-bromoacylamido) derivatives (II) and its condensation with dimethylamine. Of the starting materials (I), the 5-chloro derivative (VIII) was obtained by the oxidative cyclization from (3-chlorophenyl) thiourea with bromine but the 7-chloro derivative (IX) was also obtained as a by-product. (VIII) was confirmed by its identification with the compound obtained by reductive cyclization of 5-chloro-2-thiocyanatonitrobenzene (X).