含窒素環化合物の合成 (第106報)

2-(N-アリルグリシル) アミノチアゾール誘導体について

抄録

In order to study the presence of a tuberculostatic activity, (N-arylglycylamino)-thiazole derivatives were synthesized. By the application of bromoacetyl bromide and pyridine on ethyl 2-amino-4(or 5)-thiazolecarboxylate, 2-bromoacetamidothiazole derivatives were obtained, which gave 2-(N-arylglycyl) aminothiazole derivatives by the condensation with aromatic amines. By the application of hydrazine hydrate on ethyl 2-(N-arylglycyl) amino-4-thiazolecarboxylate, 2-(N-arylglycyl) aminothiazole-4-carbohydrazides were prepared but in a very poor yield, and the main product was arylaminomethanecarbohydrazides (tuberculostatic data shown).