YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
ジアリルジサルファイド系化合物の製造法の研究 (第5報)
ヨウ素触媒の共存下に赤燐を用いるアレーンスルホニルクロライド関連化合物に対する還元反応
河原 清
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1957 年 77 巻 9 号 p. 972-977

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The Ekbom method improved by the writer was applied to compounds possessing atomic groups related to sulfonyl chloride. The sulfonic acid and sulfone are not reduced but sulfinic acid, sulfenyl chloride, selfenamide, disulfoxide, and sulfohydrazide easily form corresponding disulfides under the reaction conditions selected. It was also found that sulfonamides and sulfoxides would be reduced under a more drastic conditions. As a result, the reduction mechanism for the formation of disulfide from sulfonyl chloride, sulfohydrazide, and sulfonamide was assumed to be in a following process:
-SO2Cl → -SOCl → -SO2H → -SO2-S- → -S-S-
-SO2NHNH2 → -SO2H → -SO2-S- → -S-S-
-SO2NH2 → -SONH2 → -SO2H → -S-S-

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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