YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
水溶性ビタミンA誘導体の合成
中川 俊夫宗行 龍之祐森 芳夫
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1957 年 77 巻 9 号 p. 984-988

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Water-soluble vitamin A derivative was obtained by the formation of an ester of vitamin A alcohol and methoxypolyethyleneoxyglycolic acid, prepared from methoxypolyethyleneglycol. As the esterification reaction, dehydrochlorination from acid chloride and vitamin A alcohol, ester exchange between methyl ester of an acid and vitamin A alcohol, and removal of potassium chloride from acid chloride and potassium salt of vitamin A were examined and it was found that all these processes afforded water-soluble, yellow ester by purification of the reaction product by chromatography through weak alumina. The ultraviolet absorption spectrum of this ester was identical with that of vitamin A alcohol.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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