YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Hydroxymethylpyrimidine同族体とビタミンB6との関係 (第2報)
Hydroxymethylpyrimidine同族体のビタミンB6欠乏促進作用について
新谷 茂
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ジャーナル フリー

1957 年 77 巻 9 号 p. 993-996

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Acceleration of pyridoxine deficiency was examined with 2, 5-dimethyl-4-aminopyrimidine (I) and 2, 6-dimethyl-4-aminopyrimidine (II), the homologs of 2-methyl-4-amino-5-hydroxymethylpyrimidine (OMP) and possessing a specific spasmodic action. Healthy rats of H-1 strain, weighing 40-60g., were fed with synthetic pyridoxine-deficient diet containing 1mg. of the compound per rat per day. The rats in the group administered with (I) in the diet failed to grow after 1-2 weeks and showed a marked symptoms of pyridoxine deficiency after 5 weeks, indicating the same results as with the control group administered with OMP. On the other hand, the rats in the group administered with (II) in the diet showed the same growth curve as those in the control group with pyridoxine-deficient diet alone. According to histological observations of the livers and kidneys of these rats after 5 weeks, marked damages were observed in those fed with (I) or OMP but there was no abnormality in the group fed with (II), as in the control group with pyridoxine-deficient diet.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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