YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
蛇毒蛋白の研究 (第2報)
蛇毒のアルカリ性フォスファターゼについて
鈴木 友二岩永 貞昭
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1958 年 78 巻 4 号 p. 354-361

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Examinations were made for conditions in measuring the activity of alkaline phosphatase in snake venom. It was found that phosphodiesterase activity is suppressed by glycine while the activity of phosphomonoesterase increases in the presence of glycine. The activities of 5′-nucleotidase, phosphomonoesterase, and glycerophosphatase are suppressed by Zn2+. Since a fair amount of Zn2+ is contained in crude snake venom, absence of phosphomonoesterase and glycerophosphatase in snake venom has been reported to date. Measurement of activity by the improved method has shown that phosphodiesterase, phosphomonoesterase, 5′-nucleotidase, and glycerophosphatase are present together always in 10 kinds of domestic and Formosan snake venom examined. The amount of these enzymes differed somewhat according to the kind of snake venom and the activity of alkaline phosphatase is generally stronger in snake venom from cobras (Elapidae) than that from asps (Crotalidae). Both phosphomonoesterase and glycerophosphatase are non-specific monoesterases but optimal pH and temperature of the two are different and there is a difference between the two as to their stability to heat and pH.

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