YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
抗黴剤の合成化学的研究 (第5報)
2-メチル-6-ベンゾチアゾールカルボン酸ヒドラジッド及びその関連化合物の合成
西海枝 東雄吉名 重多賀
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1958 年 78 巻 4 号 p. 376-380

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Ethyl 2-methyl-6-benzothiazolecarboxylate was principally prepared by thiocyanation, reduction, and ring formation from thiazole with acetic anhydride in the presence of zinc dust from ethyl p-aminobenzoate. 2-Methyl-6-benzothiazolecarbo-hydrazide was readily synthesized by condensation of the above ethyl ester with hydrazine hydrate. The acid hydrazide obtained was condensed with ten organic acid chlorides. The ten new condensed products so obtained were submitted to bacteriological screening in order to find new antifungal and antitubercal agents. Ethyl 2-amino-6-benzothiazolecarboxylate from ethyl 3-thiocyano-4-aminobenzoate was prepared only by fusion under intramolecular condensation.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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