プロテクティブコーティングの研究 (第2報)

糖類および多価アルコール類のアミン誘導体について

抄録

Amine derivatives of sugars and polyhydric alcohols were prepared and their utility as the protective coating agent was examined. The amine derivatives of sugars were prepared either by refluxing glucose, xylose, or lactose with various amines in alcohol or by the application of various amines to sucrose, dextrin, and mannitol p-toluenesulfonates. Of these various amine derivatives, dodecylamine N-lactoside and N-xyloside were the only ones that possessed resistance to water, solubility in gastric juice, and ability to form a membrane. These were used as a coating on starch-lactose tablets and their resistance to water and solubility in gastric juice were tested by measuring the duration of disintegration in distilled water and simulated gastric fluid. Both derivatives were found to be excellent agent for a protective coating.