Pyrimidine誘導体の合成研究 (第8報)

2-Dialkoxymethyl-3-alkoxypropionitrileの合成

抄録

Application of alcohol to cis- and trans-2-alkoxymethylene-3-alkoxypropionitrile and 2-dialkoxymethyl-acrylonitrile, with acid or alkali as a catalyst, was found to effect facile addition of the alcohol to form the acetal-type compounds, 2-dialkoxymethyl-3-alkoxypropionitriles, evidenced by their elemental analytical values and infrared absorption spectra. In this reaction, some 2-dialkoxymethyl-acrylonitriles formed and transetherification of the starting 2-alkoxymethylene-3-alkoxypropionitriles and the formed 2-alkoxymethylene-3-alkoxypropionitriles was observed.