1958 年 78 巻 8 号 p. 849-853
As a starting material required for the synthesis of 2-carboxy-3-pyrrolidineacetic acid, ethyl 4-cyanocrotonate (VI) was prepared by heating ethyl 4-chlorocrotonate (V) or ethyl 4-bromocrotonate (VIII) with copper cyanide. (VI) was also obtained by hydrolysis followed by decarboxylation of diethyl 2-cyanoethylmalonate (X), bromination to ethyl 2-bromo-4-cyanobutyrate (XIII), and final dehydrobromination.