YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
アキカラマツThalictrum Thunbergii DC.のアルカロイド研究(第4報)
根部第三級塩基Thalicthuberineの構造
藤田 栄一富松 利明
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1959 年 79 巻 10 号 p. 1252-1255

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A new tertiary non-phenolic base, thalicthuberine, was isolated as colorless silky crystals, m.p. 126-127°, from the root of Thalictrum Thunbergii DC (Ranunculaceae) from Tokushima. The composition and empirical formula of this substance corresponded to C21H23O4N=C16H9(OCH3)2(N(CH3)2)(-O-CH2-O-). Its ultraviolet spectrum suggested the presence of a phenanthrene skeleton. It was optically inactive.
On the other hand, O-methyldomesticine was isolated from the commercial fruit of Nandina domestica and was derived to its methylmethine by Hofmann degradation. Comparison of this methine base and thalicthuberine by mixed fusion test, and their ultraviolet and infrared spectral analyses showed the two to be identical substances. Consequently, thalicthuberine was found to be 1-dimethylaminoethyl-3, 4-dimethoxy-6, 7-methylenedioxyphenanthrene (VII).

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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