YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
ビタミンB6誘導体の合成研究
ピリジン核置換Hydroxymethyl基の接触還元について
内藤 武男上野 勝次郎
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1959 年 79 巻 10 号 p. 1277-1280

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The hydroxymethyl groups in pyridoxine, pyridoxamine, pyridoxal, and their derivatives form deoxygenated derivatives of pyridoxine by catalytic reduction over palladium-carbon. Similarly, 2-, 3-, and 4-pyridinemethanols also form corresponding picolines by catalytic reduction. The presence of water is necessary as a solvent in the case of pyridoxine derivatives while the solvent is not required in that of pyridinemethanols. Since the acylation of the hydroxymethyl group in both derivatives results in more facile reduction to methyl group, this reaction was considered to be the direct hydrogenolysis.

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