YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
1-Aza-bicycloammonium誘導体の合成
菅澤 重彦鈴田 幸男
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1959 年 79 巻 10 号 p. 1323-1325

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Ethyl 9, 10-dimethoxy-1, 2, 3, 4, 6, 7-hexahydro-11bH-benzo [a] quinolizine-3-acetate (I) was submitted to reduction with lithium aluminum hydride and the alcohol compound (III) so obtained was derived to the bromide (III). Heating of this bromide in benzene produced intramolecular ammonium salt and 1-aza-bicyclo [3.3.1]-type compound (IV) was obtained in high yield. Similar reaction, starting with quinoline ester (V) afforded 1-azabicyclo[2.2.2]-type compound (IX).

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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