YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
神経節遮断剤としての Camphor 誘導体の研究 (第2報)
d-9-Aminocamphor 誘導体について その1
中西 美智夫
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1959 年 79 巻 11 号 p. 1363-1367

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In order to obtain ganglionic blocking agent, 9-oxocamphor oxime was reduced to 9-aminocamphor which was condensed with dialkylaminoalkyl chloride to form d-9-(dialkylaminoalkylamino) camphors (I to IV), which were further derived to their respective quaternary ammonium salts (VIII to XIII). 9-Aminocamphor was derived to 9-(chloroacetamido) camphor and 9-(chloropropionamido) camphor, which were reacted with secondary amines to form d-9-(dialkylaminoacylamino) camphors (XIV to XVIII). Quaternary ammonium salts (XIX to XXIII) of these compounds were also synthesized. Hypotensive effect was found in compounds (X) to (XII), (XXI), and (XXII).

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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