Abstract
Examinations were made on the role of hypophysis and adrenals in the appearance of analgesic activity by using normal, adrenalectomized, and hypophysectomized animals.
1) Appearance of analgesic effect from morphine requires DOCA and hydrocortisone from adrenal cortex rather than epinephrine from adrenal medullary. Hypophysis, especially the frontal, is not so necessary as adrenal.
2) Oxygen consumption by cerebrum homogenate is inhibited on addition of hydrocortisone but this inhibition becomes less on further increase in the amount of hydrocortisone added. Addition of DOCA on the contrary increased the inhibition of oxygen consumption with increasing amounts.
3) Oxygen consumption by liver homogenate behaved in contrast to the case of cerebrum, both hormones increasing the oxygen consumption. In this case, oxygen consumption tended to become greater with increasing amount of hydrocortisone.
4) Oxygen consumption by cerebrum or liver homogenate was inhibited by both morphine and Ohton but concurrent use of adrenocortical hormone fortified this inhibition as an additive effect of each substance alone.
