粉末性製剤の安定性に関する研究 (第5報)

製剤中の諸種ビタミンB₁塩の安定性 その3

抄録

Stability and hygroscopic properties of thiamine were determined with powders of vitamin B group compounded with various thiamine salts and with such powders added with L-ascrobic acid.
Addition of nicotinamide to such a powder was found to decrease the stability of thiamine and the stability of acid salt (di-salt) of thiamine was especially lowered by addition of calcium pantothenate. It was found that the stability of thiamine in vitamin B complex preparations maintained in low humidity was the worst in thiamine hydrochloride.
In the powder of B group added with ascorbic acid, stability of both thiamine and ascorbic acid are the best when sparingly soluble acid salts of thiamine is added. These results seem to indicate that the stability of thiamine in such powders is affected chiefly by the amount of moisture absorbed.