1959 年 79 巻 7 号 p. 891-896
Vitamin A-choleic acid was first prepared by Shimizu and Hatakeyama but its presence had been doubtful and its structure had only been presumed. In the present series of work, the palmitate, acetate, and alcohol of vitamin A and desoxycholic acid were dissolved in ethanol or ethanol-methanol mixture and crystals of vitamin A-choleic acid were obtained from each of them. X-Ray powder diffraction pattern showed that vitamin A palmitate-choleic acid had the same structure as methyl palmitate-choleic acid, and that vitamin A acetate- and alcohol-choleic acid had the same structure as decalin-choleic acid. Crystal lattice constants of these substances were calculated from oscillation and Weisenberg photographs. It was learned that the vitamin A palmitate-choleic acid had the same crystal structure as that of fatty acid-choleic acid, and the unit lattice in the other two substances was somewhat larger than that of fatty acid-choleic acid but was approximately the same. Infrared spectrum of vitamin A-choleic acid was the same as that of desoxycholic acid. Vitamin A in these substances is stable and not decomposed by tabletting and, since vitamin A is extracted with ether, it was proved that these substances are the channel-type inclusion compound reported by Giacomello and others.