Acridineに対するGrignard試薬の反応

抄録

Various kinds of Grignard reagent were reacted with acridine (I) in ether solution, heated at 100° for 1.5-3 hours in a sealed tube, and 9-substituted acridans (II) were obtained in good yield (Table I). Oxidation of (II) with alkaline potassium ferricyanide afforded 9-substituted acridines (III) (Table II) and this process seemed suitable as a laboratory process for preparation of (III). (III) is easily reduced to (II) with aluminum foil in methanolic solution of sodium methoxide. (II) is well crystallizable and forms crystals of a definite melting point that it is a suitable derivative of (III) for identification purposes.