YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
溶解補助剤の研究 (第2報)
酸アミド類の溶解補助機構について その1
鮫島 政義
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ジャーナル フリー

1960 年 80 巻 1 号 p. 92-95

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Acid amides are generally used as a solubilizing agent but their solubilization mechanism is still almost unknown. In order to clarify such mechanism of urea, acetamide, cyanoacetamide, nicotinamide, and isonicotinamide, whose solubilizing action was reported previously, refractive index of their aqueous solution was measured by the method of Arshid and Giles, to examine interaction, if any, between the acid amide and the solubilizate. It was thereby found that these acid amides and the solubilizate, such as phenol, benzyl alcohol, and p-toluidine, formed a complex of 1:1 molar ratio and that these amides are complex-forming solubilizing agent.

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