解熱鎮痛剤の合成研究 (第6報)

N,N-Dimethyl-2-[ethoxycarbonylおよびdialkylcarbamoyl-anilino]-alkanamide誘導体の合成

抄録

A few of the amino acid derivatives with pyrolytic structure of antipyrine and acetophenetidine, prepared earlier, were found to have antipyretic and analgesic actions. Attempts were then made to introduce benzoic acid structure, having paralytic action, into the nitrogen in amino acid, in place of the pyrolytic structure, to examine the effect, if any, on increasing analgesic activity. N, N-Dimethyl-2-(ethoxycarbonylanilino) alkanamides and N, N-dimethyl-2-(dialkylcarbamoylanilino)-alkanamides were prepared. Preparation of N, N-dimethyl-2-(o-dialkylcarbamoylanilino) alkanamide was thought to be difficult due to the effect of a substitutent in the ortho-position but the objective compounds were obtained in a good yield by a new method of synthesis.