ビタミンB₁関連化合物の微生物学的研究 (第2報)

lactobacillus fermenti-36に対する増殖促進作用

抄録

Growth-promoting effect on Lactobacillus fermenti-36 was examined in 12 kinds of compound possessing structure similar to thiamine and none of them showed any activity. Apparent activity is sometimes shown by O-chlorothiamine, O-benzoyl-thiamine, O, S-dibenzoylthiamine, 3-[(2-methyl-4-amino-5-pyrimidinyl) methyl]-4, 5-dimethylthiazolium chloride, and N-[(2-methyl-4-amino-5-pyrimidinyl) methyl]-N-[1-(2-thiacyclobutylidene) ethyl] formamide as well as the compounds which undergo chemical rearrangement to thiamine under the conditions for microbiological assay, i.e. O-acetyl-thiamine, thiamine 2-hydroxyethyl disulfide, thiamine propyl disulfide, thiamine disulfide, and thiamine tetrahydrofurfuryl disulfide, but they have no fundamental activity. Ethylthiamine has the same activity as thiamine.