ヒアルロニダーゼ水溶液の安定化

抄録

Inorganic salts generally stabilize hyaluronidase and the action is especially strong in chlorides and bromides. Heavy metal ions, Cu²⁺ and Sn⁴⁺, inactivate the enzymatic action periodically while chelation agents inhibit this action of heavy metal ions, but also seem to act protectively on the enzyme directly. Protective colloids also has the stabilizing activity. The aqueous solution of hyaluronidase-procaine, added with sodium chloride, chelation agent, and protective colloid, is extremely stable.