Abstract
Biological product of sulfisoxazole excreted in the urine after its oral administration was examined chiefly through paper chromatography and paper electrophoresis. It was thereby found that the substances excreted are sulfisoxazole, acetylsulfisoxazole, sulfanilamide, sulfisoxazole-N-sulfonate, and sulfisoxazole-N-glucuronide. Isolation of the substances excreted into the urine was carried out and sulfisoxazole, acetylsulfisoxazole, and an unknown substance were isolated. Other substances were in too minute a quantity or too labile to be isolated.