Abstract
Quantitative examinations were made on the papaverine-like spasmolytic action of various flavonoids and anthraquinones, using excised small intestine of mice. Papaverine was used as the standard and acetylcholine as the contraction agent, and the potency ratio so found is shown in Table I. It was found that some of these compounds had the same or stronger effect than the standard papaverine. It was also observed that the introduction of a large group like sugar into the molecule or increased solubility of a molecule caused decrease in spasmolytic acitivity. Preliminary tests were carried out on some sample with excised trachea of guinea pigs but only far weaker effect than the standard papaverine was observed.
