1960 年 80 巻 5 号 p. 674-679
Solubility of picolinamide, nicotinamide, isonicotinamide, and pyrazincarboxamide in water, alcohols, acetic esters, chloroform, and isoöctane at 0° and 25° (or at 30° or 38°) was measured by analytical method using ultraviolet absorption (Tables II and III). On the other hand, from the heat of sublimation and heat of fusion of these solutes, reported in Parts I and II of this series, solubility parameter was calculated (Table VI) and the values were compared with the values of solubility calculated by application of the regular solution theory (Table VII). The calculated values were smaller than found values and the two values were almost in disagreement, but the order of solubility was in good agreement with measured order and the fact that the pairs of picotinamide and pyrazincarboxamide, and nicotinamide and isonicotinamide, showed similar behavior all indicate that, as far as the measurement is limited to qualitative steps, consideration by the regular solution theory has a certain amount of significance.