薬品のポーラログラフ的研究 (第17報)

フェナジン類の直流, 交流ポーラログラフ

抄録

Phenazine-1-carboxylic acid (I) and its amide (II) show two-step, one-electron reduction wave at below pH 2. Its 1st wave is accompanied by an anomalous wave considered to be due to adsorption of to the electrode and relationship between concentration and peak height of A. C. polarography satisfies adsorption isotherm. At pH 2-13, this two-step wave becomes one-step and is treated as the two-electron, two-proton reduction wave. In weak acidity, they also indicate anomalous wave like riboflavin. Reduction potential of monosubstituted phenazines showed E-effect of the substituent in the order of COON>CONH₂>H>OH. From these polarographic behaviors, it is considered that the semiquinone compounds of (I) and (II) are stable only in strong acidity and may act as a respiratory catalyst of Pseudomonas aeruginosa.