ピリミジン誘導体の研究 (第8報)
1,2,4-Triazolopyrimidine類について その7
1960 年 80 巻 7 号 p. 956-962
詳細
1960 年 80 巻 7 号 p. 956-962
Application of benzyl chloride to 5-methyl-7-hydroxy-1, 2, 4-triazolo[4, 3-α]pyrimidine (II), m. p. 300°(decomp.), obtained by the reaction of 2-hydrazino-4-hydroxy-6-methyl-pyrimidine (I) and formic acid, gave three kinds of benzyl derivatives. One of these agreed with 5-methyl-8-benzyl-1, 2, 4-triazolo[4, 3-α]pyrimidin-7(8H)-one (VII) prepared from 2-hydrazino-3-benzyl-6-methyl-4(3H)-pyrimidone (VI) and formic acid. Heating of 3-phenyl-1, 2, 4-triazolo[4, 3-α]pyrimidines (XIV: R=H and CH3) in formic acid results in isomerizatlon to 2-phenyl-1, 2, 4-triazolo[2, 3-α]pyrimidine (XVI: R=H and CH3) which can be obtained by oxidation of N-(2-pyrlmldlnyl) benzamldlnes with lead tetraacetate.
