YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
アルキルアミノヘプタン誘導体の薬理学的研究 (第1報)
N-Alkyl-1,5-dimethylhexylamine誘導体の気管筋弛緩作用
太田 喜夫大谷 元治榎本 玲子
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1960 年 80 巻 9 号 p. 1153-1155

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In order to find some pharmaceutics which has weak hypertensive and cardiostimulation action, and powerful tonsil expansion, anticonvulsant, and anti-allergic actions, derivatives of N-alkyl-1, 5-dimethylhexylamine were prepared and their action of slackening excised tracheal muscle of a guinea pig and their acute toxicity were tested. In general, efficacy was stronger in monoalkylamines (propyl, isopropyl, butyl, isobutyl) than dialkylamines (dimethyl, diethyl, piperidyl), and all were stronger than ephedrine although they were less effective than epirenamine and diphenhydramine. Toxicity was stronger in monoalkylamine than dialkylamine and among the monoalkylamines, the iso types were less toxic than the normal type.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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