1960 年 80 巻 9 号 p. 1156-1159
Pharmacological activities in general were tested with N-isopropyl-1, 5-dimethylhexylamine hydrochloride (No. 4). The antiacetylcholine and antihistamine actions of No. 4 on excised tracheal muscle of a guinea pig were 10 times that of ephedrine and their anti-barium action was one-half that of papaverine. Similarly, antiacetylcholine and antihistamine actions on excised intestine were 2 and 100 times respectively that of ephedrine, and anti-barium action was one-tenth that of papaverine. The compound No. 4 indicated hypotensive and cardiac inhibitive actions and this point differs from the known alkylamines and aralkylated sympathomimetic amines. Its action on peripheral vessels, pupil, and saliva secretion was very weak. Its effect in preventing histamine shock was less than that of Diphenhydramine but better than that of ephedrine or methoxyphenamine.