Lipoic Acidに関する研究 (第1報)
8-Alkoxy-6-oxoöctanoic AcidおよびそのEsterの新合成法
1960 年 80 巻 9 号 p. 1165-1169
詳細
1960 年 80 巻 9 号 p. 1165-1169
2-(3-Ethoxypropionyl) cyclopentanone (XIII) was prepared by the application of 3-ethoxypropionyl chloride to 1-piperidinocyclopentene (XVIII) and (XIII) was hydrolysed by alkali into 8-ethoxy-6-oxoöctanoic acid (XV). Keto acids (XV) easily change into the methyl ester (XX) with diazomethane and esterification with alcohol, benzene, and sulfuric acid resulted in exchange reaction between the ethoxyl at 8-position with alcohol.
