YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
抗癌性物質による大腸菌の核酸, 蛋白の合成ならびに呼吸に対する阻害効果
水谷 弘子阿部 美穂子水野 伝一
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1960 年 80 巻 9 号 p. 1260-1267

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Twenty-one anticancer agents were submitted to the test for some specific inhibitory effects on the syntheses of nucleic acid and of protein by and on respiration of E. coli. Mitomycin, RC-4, and nitrogen mustard showed specific inhibitory effect on DNA synthesis. Among them mitomycin showed a lethal activity on bacterial cells in the resting stage even in a concentration of 0.01γ/cc. 4-Nitroquinoline 1-oxide and 5-methyltryptophan showed specific inhibitory effects on syntheses of RNA and protein. In addition to chloramphenicol, 5-nitro-2-furylacrylate and actinomycin showed a specific inhibition on protein synthesis in a limited range of their concentrations.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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