製剤学的研究 第12報

ビタミンA, Dの水溶化 その8 Raffinose Fatty Acid Esterによる可溶化

抄録

In order to solubilize vitamins A and D for fortification of foodstuff, substances which are allowed for use in foodstuff, such as sucrose ester, must be used as a solubilizing agent. However, some of sucrose esters suited for solubilization have unpleasant odor or taste and their use is limited. In order to improve this point, raffinose esters were prepared, and their properties and solubilization power were examined. Raffinose palmitate, oleate, and myristate are practically odorless and tasteless, dissolve well in water, and are able to solubilize vitamins A and D to form a transparent solution, thereby showing that they have solubilization power equal to the known solubilizing agents such as Tweens. Oral and parenteral toxicity of these raffinose esters showed that the former is very small and their possible use for foodstuff was suggested. However, these esters were fairly toxic by intravenous injection and this was assumed to be due to their hemolytic action, same as that of sucrose esters. Aqueous solution of vitamins A and D solubilized with raffinose ester is stable and does not become cloudy on heating.