o-Aminophenolの生体内運命について (第3報)
o-Aminophenol投与家兎尿におけるo-Aminophenol抱合体について
1961 年 81 巻 1 号 p. 53-58
詳細
1961 年 81 巻 1 号 p. 53-58
o-Aminophenol was given orally to a rabbit and substances in the urine originating from the aminophenol were examined. The presence of o-aminophenol, o-amino-phenyl glucosiduronic acid, o-aminophenyl hydrogensulfate, and o-acetamidophenol were confirmed by individual isolation. 1-o-Hydroxyanilino-1-deoxyglucuronic acid was not isolated directly but its presence was proved indirectly, while o-hydroxy-phenylsulfamic acid and 3-aminophenoxazin-2-one were not detected. Quantitative examination of these substances in the urine after oral administration of 1g. of o-aminophenol showed that approximately 7.6% of the administered aminophenol was excreted per se, 26% as o-aminophenyl glucosiduronic acid, 18% as o-aminophenyl hydrogensulfate, and 1.2% as o-acetamidophenol.
