スルホフタレイン系色素による有機塩基製剤の比色定量 (第3報)
プロピルアミン系抗ヒスタミン製剤の比色定量
1961 年 81 巻 1 号 p. 76-79
詳細
1961 年 81 巻 1 号 p. 76-79
Method of assay for antihistamines in official formularies is difficult when used for assay of preparations and the values obtained are often inaccurate. The colorimetric determination of organic bases by the sulfophthalein dyes was applied to the assay of antihistamines of propy famine series and a good result was obtained by the use of Bromocresol Green and Bromothymol Blue. At the same time, effect of substances blended in the preparations was also examined and it was found that chlorpheniramine maleate (I) alone can be selectively determined by the use of Bromothymol Blue and ethylene dichloride when aminopyrine is compounded in (I) and by the use of Bromocresol Purple or Bromophenol Blue and benzene when ephedrine hydrochloride is compounded in (I).
