α-シアノケトン類の過酸化水素分解反応の応用

脂環性α-シアノケトンからジカルボン酸の誘導

抄録

Derivation of α-cyanoketones to dicarboxylie acids was attempted by the use of decomposition of α-cyanoketones with hydrogen peroxide in dilute alkali hydroxide solution, reported previously. The reaction carried out on α-cyanocyclohexanone and 2-cyano-α-tetralone afforded the corresponding adipic acid and 2-carboxyhydro-cinnamic acid in 21-22% yield. Although this reaction does not give a good yield of the product, it is a simple process and is not accompanied by formation of by-products that it seems to be possible for use as a synthetic process for some kinds of dicarboxylie acid.