YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Tropane Alkaloidの研究 (第1報)
Tropane Alkaloid類, Hygrine, Betaine類, Xanthineのペーパークロマトグラフィー
木村 久吉
著者情報
ジャーナル フリー

1961 年 81 巻 12 号 p. 1699-1702

詳細
抄録

Tropane alkaloids widely distributed in some genera of the Solanaceae family and decomposed bases were submitted to paper chromatography with various developing solvents, in comparison with hygrine, xanthine, and betaines, which are known to be fairly widely distributed in the Solanaceae and related families, and synthesized homatropine (Table I). In tropane alkaloids, there were marked differences between the original alkaloids and their degraded bases in their Rf values by various developing solvents and coloration to the Dragendorff reagent. Hygrine, xanthine, and betaines showed different Rf values from those of tropane alkaloids and their degraded bases. This paper chromatographic procedure enabled isolation of nortropine in a good yield from scopolia extract, and isolation and identification of scopine and scopoline from the hydrolyzate of scopolamine.
Modification of the Dragendorff reagent for identification of tropane alkaloids by paper chromatography was examined. The use of hydrochloric acid in place of nitric acid and dilution with 10% potassium iodide solution were found to give a formula which is stable over a long period and give comparatively quantitative result in examining the limit of alkaloidal coloration in paper partition chromatography. Limit of detection of alkaloids and betaines, and developed area of atropine in paper partition chromatography were examined by this modified reagent.

著者関連情報
© by the PHARMACEUTICAL SOCIETY OF JAPAN
前の記事 次の記事
feedback
Top