平滑筋における薬物受容体の研究 (第3報)
シロネズミ子宮平滑筋のアセチルコリン, 塩化バリウムおよびオキシトシン受容体に対する水素イオン濃度の影響
1961 年 81 巻 12 号 p. 1717-1721
詳細
1961 年 81 巻 12 号 p. 1717-1721
In experiment with excised uterus strip of a rat, acetylcholine was inhibited noncompetitively by hydrogen ion concentration, while barium choride and oxytocin were inhibited competitively. Oxytocin was far more strongly inhibited than barium chloride by hydrogen ion and this may be considered as inhibition of dissociation of -SH group in the barium receptor. Inhibition of oxytocin is probably due to inhibition of the dissociation of phenol group of tyrosine in the oxytocin molecule.
