YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
七員環化合物の研究 (第2報)
Cyclohepta [b] pyrrol-8(1H)-one誘導体の合成
砂川 玄俊相馬 信夫中尾 英雄松本 安弘
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1961 年 81 巻 12 号 p. 1799-1806

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Condensation of 2-hydrazinotropone (I) and its derivatives with aliphatinc aldehydes or ketones afforded hydrazones which were heated with polyphosphoric acid or dilute sulfuric acid to form cyclohepta [b] pyrrol-8(1H)-one (XVI). Halogenation of 3-methyl-(XVII) and 2, 3-dimethyl-cyclohepta [b] pyrrol-8(1H)-one (XIX) was examined and it was found that their bromination with N-bromosuccinimide resulted in introduction of bromine into the ring, instead of bromination of the side chain, first in the 2-position when it is vacant and further in other positions, while the 7- and then 5-position of the seven-membered ring are brominated when there is a methyl group in 2-position.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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