YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
医薬品の吸収と排泄に関する研究 (第1報)
顆粒によるN1-(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfanilamideの作用持続化と血中濃度式の検討
掛見 喜一郎有田 隆一小泉 保
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1961 年 81 巻 2 号 p. 172-178

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Attempts were made to prolong the action of sulfaethylthiadiazole (N1-(5-ethyl-1, 3, 4-thiadiazol-2-yl)-sulfanilamide) by granulation with tristearin as the binder. Blood level of the drug was tested after administration in a rabbit and the lowering rate was found to be decreased. Blood level formula, which agreed well with observed values, was derived by the consideration of the fact that the in vitro erosion is represented by a primary reaction formula and that this erosion rate affected blood level.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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