6-Piperidino-4,4-diphenyl-3-hexanoneおよびEthyl 1,1-Diphenyl-3-piperidinopropyl Sulfone系化合物の薬理的研究 (第4報)

Ethyl d-およびl-1,1-Diphenyl-3-piperidinobutyl Sulfoneの薬理的研究

抄録

Comparative examinations were made on the pharmacological action of ethyl d- and l-1, 1-diphenyl-3-piperidinobutyl sulfones. Toxicity of the levorotatory compound by intraperitoneal injection in mice was ca. 3 times that of the dextro compound, probably 2-4 times considering respiration and blood pressure tests in rabbits. However, AD₅₀ and AtD₅₀ of the levo compound was ca. 8 and 7 times that of the dextro compound and it is interesting that analgesic and antitussive activity is 2-3 times greater than toxicity. There was no difference between dextro and levo compound in their effect against excised intestine. In antihistamine effect, the levo compound is somewhat stronger than the dextro compound, while the order is reversed in anti-acetylcholine effect, the dextro compound being stronger than levo compound. This compound causes transitory increase in number of drops in aural vessel perfusion test in a rabbit, though the action is weak, and there was no difference in this action between the dextro and levo compounds.