1961 年 81 巻 2 号 p. 195-199
In order to examine the effect of 2-phenylbutyric acid, its derivatives, and related compounds, quantitative determination of cholesterol was examined. The colorimetric determination by the digitonin method, petroleum ether method, and ferric chloride method did not show any significant difference in procedural effect. Blood cholesterol level in rats was examined and there was no significant difference according to their age, sex, and strain. Examinations were also made on hyper-cholesterolemia in a rat cawed by administration of Triton WR-1339. No change occurred on continuous subcutaneous injection of 50mg./kg./day for 2 weeks or single intravenous injection of 100mg./kg. and a linear dose-response curve was obtained up to 500mg./kg. The blood cholesterol level reached the maximum 18hours after intravenous injection of 200mg./kg. and 22hours after intraperitoneal injection of the same dose, and the level fell to the normal after 120hours.