YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
脂質代謝に関する研究 第8報
過コレステロール血症の研究 1 Triton WR-1339による過コレステロール血症作用
小林 忠之
著者情報
ジャーナル フリー

1961 年 81 巻 2 号 p. 195-199

詳細
抄録

In order to examine the effect of 2-phenylbutyric acid, its derivatives, and related compounds, quantitative determination of cholesterol was examined. The colorimetric determination by the digitonin method, petroleum ether method, and ferric chloride method did not show any significant difference in procedural effect. Blood cholesterol level in rats was examined and there was no significant difference according to their age, sex, and strain. Examinations were also made on hyper-cholesterolemia in a rat cawed by administration of Triton WR-1339. No change occurred on continuous subcutaneous injection of 50mg./kg./day for 2 weeks or single intravenous injection of 100mg./kg. and a linear dose-response curve was obtained up to 500mg./kg. The blood cholesterol level reached the maximum 18hours after intravenous injection of 200mg./kg. and 22hours after intraperitoneal injection of the same dose, and the level fell to the normal after 120hours.

著者関連情報
© by the PHARMACEUTICAL SOCIETY OF JAPAN
前の記事 次の記事
feedback
Top