脂質代謝に関する研究 第9報

過コレステロール血症の研究2コレステロール生合成の抑制剤 その1

抄録

Examinations were made on the effect of 2-phenylbutyric acid, 2-(p-biphenyl)butyric acid, their derivatives, and related compounds which had been found to inhibit endogenous cholesterol synthesis, as reported by Cottet, et al. and by Garattini, et al. Of the 10 kinds of related compounds, water-soluble sodium 2-(p-biphenyl)butyrate had the strongest effect. The effect of the sodium salt of N-(2-p-biphenylylbutyryl)taurine and sodium 2-(p-biphenyl)butyrate showed no significant difference in intraperitoneal and oral administration.