1961 年 81 巻 2 号 p. 209-214
Using the pain reaction recording apparatus, which can record pain reaction of a mouse on the hot plate, and the pressure pain apparatus, attempt was made to assay quantitatively some antipyretic analgesics, which have been thought comparatively difficult to detect.
1) In general, the antipyretic analgesics did not inhibit the primary pain reaction of mice on the hot plate, but prolonged the secondary reaction time to jump out of the hot plate. The narcotic analgesics inhibit both pain reactions completely when large quantities are applied.
2) All the pyrazolone derivatives used elevated the threshold of the secondary pain reaction of mice on the hot plate and this response increases linearly with the increasing dose of pharmaceutics.
3) It was found that the range of the effective dose of aniline and p-aminophenol derivatives was very limited and that the side effect appeared when a higher dosages were used.
4) The salicylates have only a slight analgesic activity to pain stimuli. N-Methyl-salicylamide has a higher analgesic effect than salicylamide.
5) The analgesic effect of pyrabital was comparatively high and the primary pain reaction on the hot plate was also inhibited by it.