Antitussive activity of several drugs, including antispasmodics, sympathomimetics, antihistamines, and some ω-(diphenylmethoxy)alkylamines, was examined against coughing produced in guinea pigs by mechanical stimulation. A certain relationship was found to exist between chemical structure and antitussive activity of the compounds derived from ω-(diphenylmethoxy)alkylamines. In these compounds, the highest antitussive activity was found in 1-[2-(4-chloro-α-phenylbenzyloxy)ethyl]-piperidine and 4-[2-(4-chloro-α-phenylbenzyloxy)ethyl]-1-piperazineëthanol, which were far more effective than codeine. Pharmacological properties of these two compounds were briefly examined.
