YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
鎮咳薬に関する研究 (第5報)
ナルコチンおよびナルコチンN-オキシド
高木 敬次郎福田 英臣佐藤 道子
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1961 年 81 巻 2 号 p. 266-270

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Antitussive activity and other pharmacological properties of narcotise and its N-oxide were investigated. Employing the two methods of assay for antitussive activity, it was found that the activity of narcotine N-oxide is a little stronger than narcotine (Table I). The constipating action and inhibition of gastrointestinal propulsion of these drugs could not be observed. Further, their action on blood pressure, respiration, papaverine-like antispasmodic action, and acute and subacute toxicity were examined.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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