1961 年 81 巻 2 号 p. 266-270
Antitussive activity and other pharmacological properties of narcotise and its N-oxide were investigated. Employing the two methods of assay for antitussive activity, it was found that the activity of narcotine N-oxide is a little stronger than narcotine (Table I). The constipating action and inhibition of gastrointestinal propulsion of these drugs could not be observed. Further, their action on blood pressure, respiration, papaverine-like antispasmodic action, and acute and subacute toxicity were examined.