1961 年 81 巻 2 号 p. 271-274
Combined use of pharmaceutics of similar effect is expected to give additive effect if the site of action is the same and pontentiative effect if the site of action is different. This point was examined by the combined use of codeine with other antitussives, tested by the mechanical stimulation method. It was thereby found that the combined use of hydrocodeine and codeine N-oxide, which are considered to have the same site of action, resulted in additive effect while the combined use of chlorpromazine and diphenhydramine showed potentiative effect. Narcotine potentiated the effect of codeine to some extent.