YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
パラアミノサリチル酸およびその塩の分解に関する物理化学的研究 (第3報)
水溶液中のパラアミノサリチル酸ナトリウムの見掛けの分子容, イオン容ならびに粘度
田中 信夫中垣 正幸
著者情報
ジャーナル フリー

1961 年 81 巻 4 号 p. 600-603

詳細
抄録

As it had been recognized that the reaction rate varied with concentration of sodium p-aminosalicylate, the state of solution was examined in the aqueous solution of the salt, especially on the density and viscosity. Specific gravity was measured in the range of temperatures at 20-40° and equations (5), (6), (7), (8), and (9) were obtained. Calculations were made on the apparent molal and ionic volumes and the values approximately agreed with those of p-aminosalicylic acid calculated from X-ray diffraction. Viscosity of sodium p-aminosalicylate solution was measured and relationship between ηred. and concentration was plotted in a graph. As indicated in Fig. 2, a specificity was found in the curve at around 0.5M concentration. Using the absolute reaction rate theory of Eyring, ΔFV, ΔHV, and ΔSV at 20° were calculated and, as shown in Table II, ΔHV and ΔSV were found to increase suddenly at 0.5M concentration. From these results, sodium p-aminosalicylate is considered to take a pseudomicelle structure in the solution at a concentration above 0.5M and this is thought to be related to the reaction rate.

著者関連情報
© by the PHARMACEUTICAL SOCIETY OF JAPAN
前の記事 次の記事
feedback
Top