除痛剤の合成 (第27報)
脂環, 異項環式α-アミノ酸誘導体について その1
1961 年 81 巻 4 号 p. 608-612
詳細
1961 年 81 巻 4 号 p. 608-612
Cyclohexanone was submitted to the Strecker reaction, 1-(1-methyl or -ethylamino)-cyclohexanecarbonitrile (I or II) so obtained was acylated (III to IX), and hydrolyzed with conc. sulfuric acid to form 1-(N-methyl- or -ethyl-acylamino)cyclohexanecarboxylic acid (X to XVII). Their esters (XXVII to XXXI), esters of 2-(diethylamino- or -piperidino) ethanol (XXXII to XXXV), and amides (XXXVI to XLIII) were also prepared. Reaction of aminonitrlle (I) with haloacyl halides gave 1-[N-methyl-(2-haloacyl)amino] cyclohexanecarbonitrile (XVIII and XIX) which were reacted with dialkylamine, piperidine, morpholine, or N, N-diethyl-1, 3-propanediamines to form the corresponding 1-[N-methyl-(2-dialkylaminoacyl)amino] cyclohexanecarbonitriles (XX to XXVI).
