鎮咳薬の化学的薬理学的研究 (第1報)
持続性鎮咳薬d-N,N,1-Trimethyl-3-(ethylsulfonyl)-3,3-diphenylpropylamine Hydrochlorideの薬理
1961 年 81 巻 5 号 p. 740-747
詳細
1961 年 81 巻 5 号 p. 740-747
The pharmacology of d-N, N, 1-trimethyl-3-(ethylsulfonyl)-3, 3-diphenylpropylamine hydrochloride (A-5) was described in detail. A-5 showed a long-acting antitussive activity, duration of the effect being 18.9 times that of codeine (intravenous) and 13.5 times that of codeine (oral), though 50% antitussive dose is only 1.4 and 1.7 times that of codeine in dogs and cats, respectively. The site of action seemed to be the cough center per se. Toxicity in mice (subcutaneous) is 1.5 times that of codeine and 30% that of Methadone. No tendency to establish tolerance, cumulative action, or addiction liability was found by long-term administration. Analgesic action and other actions were discussed.
