YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
局所麻酔剤の研究 (第1報)
テトラリン誘導体の合成
千田 重男和泉 弘
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1961 年 81 巻 7 号 p. 964-968

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Examinations were made on the nitration of 3, 4-dihydro-5, 7-dimethyl-1(2H)-naphthalenone (I) and 1, 2, 3, 4-tetrahydro-5, 7-dimethyl-naphthalene (II). Using the nitro compounds (V and IX) so obtained as the starting materials, compounds (XIX to XXXIII) possessing α-dialkylamino acylamino group in the 6- or 8-position were synthesized. Among these compounds, tetralin derivatives had stronger local anaesthetic action than tetralone derivatives.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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